ISO/TR 18161:2013 describes an approach for using ISO 16100 and ISO 18435 to specify information exchange requirements between applications. This approach is based on the use of ISO 18435 application integration matrix element (AIME)/application domain matrix element (ADME) templates in conjunction with ISO 16100 manufacturing software unit (MSU) capability profiles.

ISO/TR 18161:2013 also provides an example approach as applied to describing the interoperability requirements of the integrated smart pump application, which comprises the pump control application and the pump diagnostics application.